Champions Manchester City travel to West Ham on the opening weekend of the 2022-23 Premier League season.
There will be no top-flight games after the weekend of 12-13 November until 26 December because of the World Cup.
The first fixture takes place on Friday, 5 August when Crystal Palace host Arsenal.
Liverpool play at promoted Fulham, with Nottingham Forest at Newcastle.
Forest are back in the Premier League for the first time since 1998-99.
The World Cup, which will feature both England and Wales, starts on 21 November. The final is on 18 December, eight days before the Premier League season resumes.
There are no meetings between the Premier League’s so-called ‘big six’ on weekend of 12-13 November – the one before the World Cup – following a request by the Football Association.
First round of fixtures in full
Crystal Palace v Arsenal
Bournemouth v Aston Villa
Everton v Chelsea
Fulham v Liverpool
Leeds United v Wolverhampton
Leicester City v Brentford
Newcastle United v Nottingham Forest
Tottenham Hotspur v Southampton
Manchester United v Brighton
West Ham United v Manchester City
Break of more than six weeks
The 2022-23 season has been adjusted to accommodate the 2022 World Cup, which takes place in the middle of the domestic calendar.
It starts a week earlier than normal – 75 days after the final day of the 2021-22 campaign – and finishes a week later than usual on 28 May.
Fifa, world football’s governing body, has already stipulated that players must be released on 14 November for the World Cup.
It means the mid-season break will last more than six weeks.
Games on 12-13 November before World Cup
Bournemouth v Everton
Brighton v Aston Villa
Fulham v Manchester United
Liverpool v Southampton
Manchester City v Brentford
Newcastle United v Chelsea
Nottingham Forest v Crystal Palace
Tottenham Hotspur v Leeds United
West Ham United v Leicester City
Wolverhampton v Arsenal
Liverpool host Man City on 15 October
Manchester City, crowned 2021-22 champions after a dramatic final-day win over Aston Villa, are favourites to retain their title after signing forward Erling Haaland from Borussia Dortmund for £51.2m.
Haaland, 21, is set to make his Premier League debut at West Ham before City host Bournemouth and then travel to Newcastle.
Liverpool, who finished one point behind the champions in 2021-22, host City on 15 October, with the return fixture at Etihad Stadium on 1 April.
After opening the season at Newcastle, Nottingham Forest host West Ham before travelling to Everton.
The first Manchester derby of the season is on 1 October at Etihad Stadium, with United hosting their neighbours on 14 January.
Arsenal host the first north London derby of the season on 1 October with the return at Tottenham also on 14 January.
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