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The victim, in his 20s, is being treated for potentially life-changing injuries, police say.
One man has been arrested on suspicion of attempted murder and two other people have been held after an assault in Southampton.
A man in his 20s was found with serious injuries in Above Bar Street at about 04:00 BST on Sunday, police said.
A 21-year-old man from the city has been arrested on suspicion of attempted murder.
Police also arrested a 17-year-old male from Winchester on suspicion of GBH with intent and a 19-year-old man.
Officers have not said why the 19-year-old was arrested, but Hampshire Constabulary confirmed he was from Fareham.
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