People who get symptoms or test positive will no longer be legally required to self-isolate from Thursday.
All Covid restrictions will end in England on Thursday and free mass lateral flow testing will stop on 1 April, Boris Johnson has said.
The prime minister told the Commons the legal requirement to self-isolate for who tested positive would be dropped.
From 1 April, he said the provision of free rapid testing would be targeted to certain sections of the population.
The £500 isolation payment for people on low incomes will also end this week.
But Covid provisions for increased statutory sick pay would apply for a further month, Mr Johnson told MPs.
He said the efforts the country had made over the past two years meant it was now ready to move away from government restrictions and to a position of personal responsibility.